Risk of surgical site infection, acute kidney injury, and Clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: A national propensity-score-adjusted retrospective cohort study.
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ABSTRACT:
SUBMITTER: Branch-Elliman W
PROVIDER: S-EPMC5503171 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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Risk of surgical site infection, acute kidney injury, and Clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: A national propensity-score-adjusted retrospective cohort study.
Branch-Elliman Westyn W Ripollone John E JE O'Brien William J WJ Itani Kamal M F KMF Schweizer Marin L ML Perencevich Eli E Strymish Judith J Gupta Kalpana K
PLoS medicine 20170710 7
<h4>Background</h4>The optimal regimen for perioperative antimicrobial prophylaxis is controversial. Use of combination prophylaxis with a beta-lactam plus vancomycin is increasing; however, the relative risks and benefits associated with this strategy are unknown. Thus, we sought to compare postoperative outcomes following administration of 2 antimicrobials versus a single agent for the prevention of surgical site infections (SSIs). Potential harms associated with combination regimens, includin ...[more]
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