Contribution of molecular analysis to the typification of the non-functioning pituitary adenomas.

ABSTRACT:

Aim

The WHO Classification of Tumours of Endocrine Organs considers the inmunohistochemical characterization of pituitary adenomas (PA) as mandatory for patient diagnosis. Recent advances in the knowledge of the molecular patterns of these tumours could complement this classification with gene expression profiling.

Methods

Within the context of the Spanish Molecular Registry of Pituitary Adenomas (REMAH), a multicentre clinical-basic research project, we analysed the molecular phenotype of 142 PAs with complete IHC and clinical information. Gene expression levels of all pituitary hormones, type 1 corticotrophin-releasing hormone receptor, dopamine receptors and arginine vasopressin receptor 1b were measured by quantitative real-time polymerase chain reaction. In addition, we

SUBMITTER: Sanchez-Tejada L 

PROVIDER: S-EPMC5503173 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature