Bilateral effects of unilateral cerebellar lesions as detected by voxel based morphometry and diffusion imaging.

ABSTRACT: Over the last decades, the importance of cerebellar processing for cortical functions has been acknowledged and consensus was reached on the strict functional and structural cortico-cerebellar interrelations. From an anatomical point of view strictly contralateral interconnections link the cerebellum to the cerebral cortex mainly through the middle and superior cerebellar peduncle. Diffusion MRI (dMRI) based tractography has already been applied to address cortico-cerebellar-cortical loops in healthy subjects and to detect diffusivity alteration patterns in patients with neurodegenerative pathologies of the cerebellum. In the present study we used dMRI-based tractography to determine the degree and pattern of pathological changes of cerebellar white matter microstructure in patients with f

SUBMITTER: Olivito G 

PROVIDER: S-EPMC5503258 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature