Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPF activity.

ABSTRACT: If no fertilization occurs at an appropriate time after ovulation, oocyte quality deteriorates rapidly as a process called postovulatory aging. Because the postovulatory aging of oocytes has detrimental effects on embryo development and offspring, many efforts have been made to prevent oocyte aging. Here we showed that quercetin prevented the decline in oocyte quality during postovulatory aging of oocytes. Quercetin treatment reduced aging-induced morphological changes and reactive oxygen species accumulation. Moreover, quercetin attenuated the aging-associated abnormalities in spindle organization and mitochondrial distribution, preventing decrease of SIRT expression and histone methylation. Quercetin also ameliorated the decrease in maturation-promoting factor activity and the onset of a

SUBMITTER: Wang H 

PROVIDER: S-EPMC5503559 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature