FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.

ABSTRACT:

Background

FBXW7 functions as a ubiquitin ligase tagging multiple dominant oncogenic proteins and commonly mutates in colorectal cancer. Data suggest missense mutations lead to greater loss of FBXW7 function than other gene aberrations do. However, the clinicopathologic factors and outcomes associated with FBXW7 missense mutations in metastatic colorectal cancer (mCRC) have not been described.

Methods

Data were obtained from mCRC patients whose tumors were evaluated by next-generation sequencing for hotspot mutations at The University of Texas MD Anderson Cancer Center. Alterations in FBXW7 were identified, and their associations with clinicopathologic features and overall survival (OS) were evaluated.

Results

Of 855 mCRC patients, 571 had data on FBXW7 status; 43 (7.

SUBMITTER: Korphaisarn K 

PROVIDER: S-EPMC5503612 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature