Efficacy and safety comparison of chemotherapies for advanced gastric cancer: A network meta-analysis.

ABSTRACT:

Objective

Chemotherapy is one of the commonly used therapies for advanced gastric cancer. In this study, we performed a network meta-analysis on the efficacy and safety of common treatments to give evidences of their relative benefits.

Results

32 trials with 8550 patients and 20 regimens were included in this study. According to the results of primary outcomes, 5-FU plus OXA, 5-FU plus DOC, CAP plus CIS, CAP plus OXA, S-1 plus OXA and S-1 plus PAC performed well in improving OS and ORR. As for the adverse events, S-1 had a safer effect than other treatments, conversely, 5-FU plus CIS ranked the last. However, there was no regimen with outstanding performances in both efficacy and safety.

Materials and methods

Studies were searched from database and screened with crite

SUBMITTER: Sun J 

PROVIDER: S-EPMC5503642 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature