KCa1.1 channels regulate β₁-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.

ABSTRACT: Large-conductance calcium-activated potassium channel (KCa1.1; BK, Slo1, MaxiK, KCNMA1) is the predominant potassium channel expressed at the plasma membrane of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) isolated from the synovium of patients with RA. It is a critical regulator of RA-FLS migration and invasion and therefore represents an attractive target for the therapy of RA. However, the molecular mechanisms by which KCa1.1 regulates RA-FLS invasiveness have remained largely unknown. Here, we demonstrate that KCa1.1 regulates RA-FLS adhesion through controlling the plasma membrane expression and activation of β₁ integrins, but not α₄, α₅, or α₆ integrins. Blocking KCa1.1 disturbs calcium homeostasis, leading to the sust

SUBMITTER: Tanner MR 

PROVIDER: S-EPMC5503717 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature