Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults.

ABSTRACT:

Background

Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This study examined associations among IMAT content, IMCL saturation, and fasting glucose concentration in middle-aged and older adults with overweight or obesity.

Methods

Seventy-five subjects (26 males, 49 females) were recruited and thigh muscle and IMAT were assessed using magnetic resonance imaging. Vastus lateralis tissue was acquired from a subset of nine subjects and IMCL content and saturation were assessed using nonlinear dual complex microscopy.

Results

The characteristics of the 75 subjects were as follows: age 59±11 years, body mass index 30±5 kg/m², fasting g

SUBMITTER: Kim JE 

PROVIDER: S-EPMC5503871 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature