Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis.

ABSTRACT: Map3k8 has been proposed as a useful target for the treatment of inflammatory diseases. We show here that during lipopolysaccharide-induced emergency granulopoiesis, Map3k8 deficiency strongly impairs the increase in circulating mature (Ly6G^highCD11b⁺) and immature (Ly6G^lowCD11b⁺) neutrophils. After chimaeric bone marrow (BM) transplantation into recipient Map3k8^-/- mice, lipopolysaccharide treatment did not increase circulating Ly6G^highCD11b⁺ cells and strongly decreased circulating Ly6G^lowCD11b⁺ cells. Lipopolysaccharide-treated Map3k8^-/- mice showed decreased production of granulocyte colony-stimulating factor (G-CSF), a key factor in neutrophil expansion, and a Map3k8 inhibitor

SUBMITTER: Sanchez A 

PROVIDER: S-EPMC5503936 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature