The Staphylococcus aureus α-Acetolactate Synthase ALS Confers Resistance to Nitrosative Stress.

ABSTRACT: Staphylococcus aureus is a worldwide pathogen that colonizes the human nasal cavity and is a major cause of respiratory and cutaneous infections. In the nasal cavity, S. aureus thrives with high concentrations of nitric oxide (NO) produced by the innate immune effectors and has available for growth slow-metabolizing free hexoses, such as galactose. Here, we have used deep sequencing transcriptomic analysis (RNA-Seq) and ¹H-NMR to uncover how S. aureus grown on galactose, a major carbon source present in the nasopharynx, survives the deleterious action of NO. We observed that, like on glucose, S. aureus withstands high concentrations of NO when using galactose. Data indicate that this resistance is, most likely, achieved through a distinct metabolism t

SUBMITTER: Carvalho SM 

PROVIDER: S-EPMC5504149 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature