Metabolic Characterization of a Novel RORα Knockout Mouse Model without Ataxia.

ABSTRACT: The retinoic acid receptor-related receptor α (RORα) is a nuclear receptor that plays an important role in regulation of metabolism and the immune system. Genetic deletion of the receptor yields mice with significant cerebellar developmental issues associated with severe ataxia. Although many metabolic studies have been performed in these models, the impaired locomotor activity of these mice is known to affect their normal mobility and feeding behaviors. This creates some difficulty in interpretation of the role of RORα in models of metabolic disease where feeding and muscle function is a critical component of the pathophysiology. We generated a mouse with a floxed Rora allele that we crossed with a mouse line expressing Cre recombinase under the control of the EIIa promoter to obta

SUBMITTER: Billon C 

PROVIDER: S-EPMC5504173 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature