Associations between ABO blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival.

ABSTRACT: Both serology-based and genetic studies have reported an association between pancreatic cancer risk and ABO blood groups. We have investigated this relationship in a cohort of pancreatic cancer patients from Western Norway (n = 237) and two control materials (healthy blood donors, n = 379; unselected hospitalized patients, n = 6149). When comparing patient and blood donor ABO allele frequencies, we found only the A₁ allele to be associated with significantly higher risk for pancreatic ductal adenocarcinoma (PDAC) (23.8% vs. 17.9%; OR = 1.43, P = 0.018). Analyzing phenotypes, blood group A was more frequent among PDAC cases than blood donors (50.8% vs. 40.6%; OR = 1.51, P = 0.021), an enrichment fully explained by the A₁ subgroup. Blood group O frequency was lower in c

SUBMITTER: El Jellas K 

PROVIDER: S-EPMC5504338 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature