A small molecule screening to detect potential therapeutic targets in human podocytes.

ABSTRACT:

Widmeier e, tan w, airik m, hildebrandt f

A small molecule screening to detect potential therapeutic targets in human podocytes. Am J Physiol Renal Physiol 312: F157-F171, 2017. First published October 19, 2016; doi:10.1152/ajprenal.00386.2016. Steroid-resistant nephrotic syndrome (SRNS) inevitably progresses to end-stage kidney disease, requiring dialysis or transplantation for survival. However, treatment modalities and drug discovery remain limited. Mutations in over 30 genes have been discovered as monogenic causes of SRNS. Most of these genes are predominantly expressed in the glomerular epithelial cell, the podocyte, placing it at the center of the pathogenesis of SRNS. Podocyte migration rate (PMR) represents a relevant intermediate phenotype of disease in monogenic causes o

SUBMITTER: Widmeier E 

PROVIDER: S-EPMC5504421 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature