Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling.

ABSTRACT:

Background/objectives

Higher visceral fat mass (VFM) is associated with an increased risk for developing cardio-metabolic diseases. The mechanisms by which an unhealthy diet pattern may influence visceral fat (VF) development has yet to be examined through cutting-edge multi-omic methods. Therefore, our objective was to examine the dietary influences on VFM and identify gut microbiome and metabolite profiles that link food intakes to VFM.

Subjects/methods

In 2218 twins with VFM, food intake and metabolomics data available we identified food intakes most strongly associated with VFM in 50% of the sample, then constructed and tested the 'VFM diet score' in the remainder of the sample. Using linear regression (adjusted for covariates, including body mass index and total fat mas

SUBMITTER: Pallister T 

PROVIDER: S-EPMC5504448 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature