Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) patients late after surgical repair. In this study, we aimed to identify the specific patterns of circulating miRNAs in blood of patients with repaired, non-syndromic TOF and to assess whether these specific miRNAs may be useful to differentiate patients with and without heart failure.

Methods

SurePrint™ 8 × 60 K Human v16 miRNA arrays were used to determine miRNA expression profiles in 15 healthy controls and 37 patients after TOF repair of whom 3 had symptomatic right heart failure. The expression levels of selected miRNAs have been validated by quantitative

SUBMITTER: Abu-Halima M 

PROVIDER: S-EPMC5504636 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature