Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy.

ABSTRACT:

Background

Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. This study was designed to determine the functional capacity of the immune system in adult patients with AML who have completed chemotherapy and are potential candidates for immunotherapy.

Methods

We used the response to seasonal influenza vaccination as a surrogate for the robustness of the immune system in 10 AML patients in a complete remission post-chemotherapy and performed genetic, phenotypic, and functional characterization of adaptive immune cell subsets.

Results

Only 2 patients generated protective titers in response to vaccination, and a majority of patients had abnormal frequencies of transitional and m

SUBMITTER: Goswami M 

PROVIDER: S-EPMC5504716 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature