Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06.

ABSTRACT:

Background

Bacillus pumilus can secret abundant extracellular enzymes, and may be used as a potential host for the industrial production of enzymes. It is necessary to understand the metabolic processes during cellular growth. Here, an RNA-seq based transcriptome analysis was applied to examine B. pumilus BA06 across various growth stages to reveal metabolic changes under two conditions.

Results

Based on the gene expression levels, changes to metabolism pathways that were specific to various growth phases were enriched by KEGG analysis. Upon entry into the transition from the exponential growth phase, striking changes were revealed that included down-regulation of the tricarboxylic acid cycle, oxidative phosphorylation, flagellar assembly, and chemotaxis signaling. In contra

SUBMITTER: Han LL 

PROVIDER: S-EPMC5504735 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature