Genome analysis of Clostridium perfringens isolates from healthy and necrotic enteritis infected chickens and turkeys.

ABSTRACT:

Objective

Clostridium perfringens causes gastrointestinal diseases in both humans and domestic animals. Type A strains expressing the NetB toxin are the main cause of necrotic enteritis (NE) in chickens, which has remarkable impact on animal welfare and production economy in the international poultry industry. Three pathogenicity loci NELoc-1, -2 and -3 and a collagen adhesion gene cnaA have been found to be associated with NE in chickens, whereas the presence of these has not been investigated in diseased turkeys. The purpose was to investigate the virulence associated genome content and the genetic relationship among 30 C. perfringens isolates from both healthy and NE infected chickens and turkeys, applying whole-genome sequencing.

Results

NELoc-1, -3, netB and cnaA were s

SUBMITTER: Ronco T 

PROVIDER: S-EPMC5504799 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature