Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY).

ABSTRACT:

Aims/hypothesis

We sought to assess the frequency, determinants and prognosis for future diabetes in individuals with islet autoimmunity and whether these factors differ depending on the age of onset of islet autoimmunity.

Methods

A prospective cohort (n = 2547) of children from the general population who had a high-risk HLA genotype and children who had a first-degree relative with type 1 diabetes were followed for up to 21 years. Those with the persistent presence of one or more islet autoantibodies were categorised as early-onset (<8 years of age, n = 143, median 3.3 years) or late-onset (≥8 years of age, n = 64, median 11.1 years), and were followed for a median of 7.4 and 4.7 years, respectively. Progression to diabetes was evaluated by Kaplan-Meier analysis with logran

SUBMITTER: Frohnert BI 

PROVIDER: S-EPMC5504909 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature