Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents.

ABSTRACT:

Context

Traditional risk factors for type 2 diabetes mellitus are weak predictors of changes in glucose tolerance and insulin sensitivity in youth.

Objective

To identify early metabolic features of insulin resistance (IR) in youth and whether they predict deterioration of glycemic control.

Design and setting

A cross-sectional and longitudinal study was conducted at the Yale Pediatric Obesity Clinic.

Patients and intervention

Concentrations of α-hydroxybutyrate, β-hydroxybutyrate, lactate, and branched-chain amino acids (BCAAs) were measured by nuclear magnetic resonance spectroscopy in 78 nondiabetic adolescents during an oral glucose tolerance test (OGTT). Associations between baseline metabolic alterations and longitudinal changes in glucose control were test

SUBMITTER: Trico D 

PROVIDER: S-EPMC5505187 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature