The Adequate Corpus Luteum: miR-96 Promotes Luteal Cell Survival and Progesterone Production.

ABSTRACT:

Context

Inadequate progesterone production from the corpus luteum is associated with pregnancy loss. Data available in model species suggest important roles of microRNAs (miRNAs) in luteal development and maintenance.

Objective

To comprehensively investigate the involvement of miRNAs during the ovarian follicle-luteal transition.

Design

The effects of specific miRNAs on survival and steroid production by human luteinized granulosa cells (hLGCs) were tested using specific miRNA inhibitors. Candidate miRNAs were identified through microarray analyses of follicular and luteal tissues in a bovine model.

Setting

An academic institution in the United Kingdom associated with a teaching hospital. hLGCs were obtained by standard transvaginal follicular-fluid aspiration

SUBMITTER: Mohammed BT 

PROVIDER: S-EPMC5505194 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature