Association of In Vivo Adipose Tissue Cellular Kinetics With Markers of Metabolic Health in Humans.

ABSTRACT:

Context

Adipose tissue (AT) expansion occurs by hypertrophy and hyperplasia. Impaired hyperplasia, or adipogenesis, has been associated with obesity-related diseases.

Objective

We examined how in vivo adipogenesis in the subcutaneous abdominal (scABD) and femoral (scFEM) depots (via 8-week incorporation of deuterium) correlates with markers of metabolic health.

Design

Data from 52 women with obesity [27 black and 25 white; 29.7 ± 5.5 years; body mass index (BMI) 32.2 ± 2.8 kg/m2; 44.3% ± 4.0% body fat] were analyzed at Pennington Biomedical Research Center.

Main outcomes

A linear repeated measure model was used to assess the fraction of new adipose cells and the associated covariates. Akaike information criterion determined the covariates that best described th

SUBMITTER: White UA 

PROVIDER: S-EPMC5505198 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature