Pulsatile GnRH Therapy May Restore Hypothalamus-Pituitary-Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial.

ABSTRACT:

Context

The effectiveness of pulsatile gonadotropin-releasing hormone (GnRH) therapy in patients with congenital combined pituitary hormone deficiency (CCPHD) has not been investigated because of the limited number of patients, as well as these patients' presumed pituitary hypoplasia, poor gonadotrophic cell reserve, and impaired gonadotrophic response to GnRH.

Objective

To assess the pituitary response to pulsatile GnRH therapy in men with CCPHD.

Design

Prospective, self-controlled, 3-month clinical trial.

Settings

University endocrine clinic.

Patients

Men with hypogonadotropic hypogonadism caused by CCPHD.

Intervention

Pulsatile GnRH was administered subcutaneously for 3 months.

Main outcome measures

Primary endpoints were total serum tes

SUBMITTER: Zheng J 

PROVIDER: S-EPMC5505206 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature