Particulate matter air pollution and liver cancer survival.

ABSTRACT: Particulate matter (PM) air pollution exposure has been associated with cancer incidence and mortality especially with lung cancer. The liver is another organ possibly affected by PM due to its role in detoxifying xenobiotics absorbed from PM. Various studies have investigated the mechanistic pathways between inhaled pollutants and liver damage, cancer incidence, and tumor progression. However, little is known about the effects of PM on liver cancer survival. Twenty thousand, two hundred and twenty-one California Cancer Registry patients with hepatocellular carcinoma (HCC) diagnosed between 2000 and 2009 were used to examine the effect of exposure to ambient PM with diameter <2.5 μm (PM_2.5 ) on HCC survival. Cox proportional hazards models were used to estimate hazard ratios (HR

SUBMITTER: Deng H 

PROVIDER: S-EPMC5505313 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature