Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study.

ABSTRACT:

Background and purpose

Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke.

Methods

We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders.

Results

SUBMITTER: Saber H 

PROVIDER: S-EPMC5505338 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature