Neural correlates of autobiographical problem-solving deficits associated with rumination in depression.

ABSTRACT:

Background

Analytical rumination can be characterized as negative thoughts focused on searching for answers to personal problems. Failure to think concretely during autobiographical problem-solving (APS) is hypothesized to drive the inability of ruminators to generate effective solutions. Clarifying the brain correlates underlying APS deficits in depressed ruminators may identify novel biological targets for treatment.

Method

Forty participants (22 unmedicated depressed and 18 never-depressed adults) ranging in rumination engaged in APS and negative self-referential processing (NSP) of negative trait adjectives during fMRI. We contrasted activation during APS with activation during NSP to isolate regions contributing to APS.

Results

Rumination was associated with havi

SUBMITTER: Jones NP 

PROVIDER: S-EPMC5505343 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature