Patterns and Timing of Initial Relapse in Pathologic Stage II Melanoma Patients.

ABSTRACT:

Purpose

Pathologic stage II melanoma patients have variable outcomes when divided by substage. We hypothesized that an understanding of the patterns of initial relapse by substage will better inform follow-up guidelines.

Methods

We performed a retrospective review of 738 adult patients with pathologic stage II cutaneous melanoma treated at Memorial Sloan Kettering Cancer Center between 1993 and 2013. Clinical records were reviewed to determine time, location, and method of detection of initial relapse.

Results

At a median follow-up of 52 months, 219 patients relapsed. Relapses were detected more frequently in higher substages. Initial relapses were most commonly local/in-transit for IIA and IIB and systemic for IIC. Lung and brain were the most frequent sites of syste

SUBMITTER: Lee AY 

PROVIDER: S-EPMC5505631 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature