Implications of the Hierarchical Structure of Psychopathology for Psychiatric Neuroimaging.

ABSTRACT: Research into the neurobiological substrates of psychopathology has been impeded by heterogeneity within diagnostic categories, comorbidity among mental disorders, and the presence of symptoms that transcend diagnostic categories. Solutions to these issues increasingly focus neurobiological research on isolated or narrow groupings of symptoms or functional constructs rather than categorical diagnoses. Here we argue for a more integrative approach that also incorporates the broad hierarchical structure of psychopathological symptoms and their etiological mechanisms. This approach places clinical neuroscience research in the context of a hierarchy of empirically defined factors of symptoms such as internalizing disorders, externalizing disorders, and the general factor of psychopathology. Ap

SUBMITTER: Zald DH 

PROVIDER: S-EPMC5505667 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature