Association of Anisocytosis with Markers of Immune Activation and Exhaustion in Treated HIV.

ABSTRACT:

Background

Treated HIV infection is associated with heightened inflammation which can contribute to increased risk of cardiovascular disease (CVD). We have previously shown that anisocytosis, as measured by red cell distribution width (RDW), is independently associated with prevalent CVD in people living with HIV (PLHIV). In this study, we sought to identify immune correlates of RDW in PLHIV receiving antiretroviral therapy.

Methods

We performed a cross-sectional and longitudinal analysis of 147 virally-suppressed PLHIV, who had LDL < 130 mg/dL and evidence of heightened inflammation, in a randomized trial of statin therapy. A complete blood count and biomarkers of inflammation and immune activation/exhaustion were measured in peripheral blood at entry and after 24 and 48 we

SUBMITTER: Al-Kindi SG 

PROVIDER: S-EPMC5505669 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature