Tumor-Associated Macrophage Infiltration in Colorectal Cancer Liver Metastases is Associated With Better Outcome.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) support growth in most human cancers, with the notable exception of colorectal adenocarcinoma, in which TAM infiltration of primary tumors is correlated with a better outcome. The importance of TAMs in colorectal liver metastases (CLM) is unknown.

Methods

Using a tissue microarray of CLM resected at their institution from 1998 to 2000, the authors quantified immune marker expression by immunohistochemistry (IHC) using Metamorph Image Analysis software. Findings showed that CD68, CD3, CD4, CD8, FoxP3, and MHC-I were correlated with overall survival (OS) and disease-free survival (DFS).

Results

Tumor cores from 158 patients were analyzed. The median follow-up period was 117 months for survivors (n = 39). The univariate anal

SUBMITTER: Cavnar MJ 

PROVIDER: S-EPMC5505689 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature