The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis.

ABSTRACT: Responding to systemic demands in producing and replenishing end-effector blood cells is predicated on the appropriate delivery and interpretation of extrinsic signals to the HSPCs. The data presented herein implicate the systemic, extracellular form of the glycosyltransferase ST6Gal-1 in the regulation of late-stage neutrophil development. ST6Gal-1 is typically a membrane-bound enzyme sequestered within the intracellular secretory apparatus, but an extracellular form is released into the blood from the liver. Both human and murine HSPCs, upon exposure to extracellular ST6Gal-1 ex vivo, exhibited decreased proliferation, diminished expression of the neutrophilic primary granule protein MPO, and decreased appearance of CD11b⁺ cells. HSPC suppression was preceded by decreased STAT

SUBMITTER: Dougher CWL 

PROVIDER: S-EPMC5505748 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature