Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.

ABSTRACT: Imaging genetics and genomics research has begun to provide insight into the molecular and genetic architecture of neural phenotypes and the neural mechanisms through which genetic risk for psychopathology may emerge. As it approaches its third decade, imaging genetics is confronted by many challenges, including the proliferation of studies using small sample sizes and diverse designs, limited replication, problems with harmonization of neural phenotypes for meta-analysis, unclear mechanisms, and evidence that effect sizes may be more modest than originally posited, with increasing evidence of polygenicity. These concerns have encouraged the field to grow in many new directions, including the development of consortia and large-scale data collection projects and the use of novel methods (e.

SUBMITTER: Bogdan R 

PROVIDER: S-EPMC5505787 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature