Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study.

ABSTRACT:

Background

Platelets have been involved in both immune surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to sepsis in critical illness remains unknown. The aim of this work was to identify platelet markers that could predict sepsis occurrence in critically ill injured patients.

Methods

This single-center, prospective, observational, 7-month study was based on a cohort of 99 non-infected adult patients admitted to ICUs for elective cardiac surgery, trauma, acute brain injury, and post-operative prolonged ventilation and followed up during ICU stay. Clinical characteristics and severity score (SOFA) were recorded on admission. Platelet activation markers, including

SUBMITTER: Layios N 

PROVIDER: S-EPMC5505890 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature