Role of DNA methylation in the dietary restriction mediated cellular memory.

ABSTRACT: An important facet of dietary restriction (DR) that has been largely overlooked is that DR can have early effects that create a cellular memory, which persists even when DR is discontinued. The goal of this study was to determine if DNA methylation played a role in the cellular memory of DR by examining the effect of short-term DR on gene expression and DNA methylation and determining if the changes in expression and DNA methylation persist when DR is discontinued and mice returned to ad libitum (AL) feeding. We show that DR can induce substantial changes in gene expression within 1 month of its implementation in various tissues, and more interestingly, ~19-50% of these changes in gene expression persist across the tissues even when DR is discontinued. We then determined whether DR induced

SUBMITTER: Unnikrishnan A 

PROVIDER: S-EPMC5505897 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature