Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans.

ABSTRACT: The metabolic and endocrine functions of adipose tissue and the ability of organisms to cope with cellular stress have a direct impact on physiological ageing and the aetiology of various diseases such as obesity-related pathologies and cancer. The endocrine effects of adipose tissue are mediated by secreted adipokines, which modulate metabolic processes and influence related maladies. Although a plethora of molecules and signaling pathways associate ageing with proteotoxic stress and cellular metabolism, our understanding of how these pathways interconnect to coordinate organismal physiology remains limited. We dissected the mechanisms linking adiponectin signalling pathways and endoplasmic reticulum (ER) proteotoxic stress responses that individually or synergistically affect longevity i

SUBMITTER: Kyriakakis E 

PROVIDER: S-EPMC5505976 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature