Ontology highlight
ABSTRACT:
SUBMITTER: Pafumi I
PROVIDER: S-EPMC5505983 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Pafumi Irene I Festa Margherita M Papacci Francesca F Lagostena Laura L Giunta Cristina C Gutla Vijay V Cornara Laura L Favia Annarita A Palombi Fioretta F Gambale Franco F Filippini Antonio A Carpaneto Armando A
Scientific reports 20170711 1
Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking endogenous TPCs. In view of the control exerted by TPC2 on intracellular calcium signaling, we demonstrated that naringenin dampens intracellular calcium responses of human endothelial cells stimulated with VEGF, histamine or NAADP-AM, but not w ...[more]