Activated Monocytes Enhance Platelet-Driven Contraction of Blood Clots via Tissue Factor Expression.

ABSTRACT: Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, the role of inflammatory cells in contraction of blood clots and thrombi has not been investigated. The aim of this work was to study the influence of activated monocytes on clot contraction. The effects of monocytes were evaluated using a quantitative optical tracking methodology to follow volume changes in a blood clot formed in vitro. When a physiologically relevant number of isolated human monocytes pre-activated with phorbol-12-myristate-13-acetate (PMA) were added back into whole blood, the extent and rate of clot contraction were increased compared to addition of non-activated cel

SUBMITTER: Peshkova AD 

PROVIDER: S-EPMC5506001 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature