Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest.

ABSTRACT: Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns - or states - are dete

SUBMITTER: Cabral J 

PROVIDER: S-EPMC5506029 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature