Injectable hybrid system for strontium local delivery promotes bone regeneration in a rat critical-sized defect model.

ABSTRACT: Strontium (Sr) has been described as having beneficial influence in bone strength and architecture. However, negative systemic effects have been reported on oral administration of Sr ranelate, leading to strict restrictions in clinical application. We hypothesized that local delivery of Sr improves osteogenesis without eliciting detrimental side effects. Therefore, the in vivo response to an injectable Sr-hybrid system composed of RGD-alginate hydrogel cross-linked in situ with Sr and reinforced with Sr-doped hydroxyapatite microspheres, was investigated. The system was injected in a critical-sized bone defect model and compared to a similar Sr-free material. Micro-CT results show a trend towards higher new bone formed in Sr-hybrid group and major histological differences were observed bet

SUBMITTER: Henriques Lourenco A 

PROVIDER: S-EPMC5506032 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature