A Five-Region Hypothesis Test for Exposure-Disease Associations.

ABSTRACT: Characterizing exposure-disease associations is a central issue in epidemiology, one which epidemiologists often approach by adopting the index of the odds ratio and presenting its point estimate, p-value and confidence interval. In this study, the parameter space of the odds ratio is partitioned into five mutually exclusive regions corresponding to 'strong protective factor', 'weak protective factor', 'no association', 'weak risk factor', and 'strong risk factor', respectively. The authors presented a suite of statistical methods tailored to such a five-region demarcation, including methods for hypothesis testing, confidence interval estimation and calculation of the sample size needed to obtain the desired level of statistical power. The authors show that the five-region methods can effi

SUBMITTER: Shih HY 

PROVIDER: S-EPMC5506070 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature