Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

ABSTRACT: Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO^+/- ) or homozygous (PerIRKO^-/- ) disruption of the IR in peripheral tissue of 15-weeks-old mice using a tamoxifen-inducible Cre transgenic mouse with only peripheral tissue expression, and subsequently monitored glucose metabolism, insulin signalling and spontaneous death rates over 4 years. Complete peripheral IR disruption resulted in a diabetic phenotype with increased blood glucose and plasma insulin levels in young mice. Although blood glucose levels returned to normal, and

SUBMITTER: Merry TL 

PROVIDER: S-EPMC5506415 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature