Genetic interplay between human longevity and metabolic pathways - a large-scale eQTL study.

ABSTRACT: Human longevity is a complex phenotype influenced by genetic and environmental components. Unraveling the contribution of genetic vs. nongenetic factors to longevity is a challenging task. Here, we conducted a large-scale RNA-sequencing-based expression quantitative trait loci study (eQTL) with subsequent heritability analysis. The investigation was performed on blood samples from 244 individuals from Germany and Denmark, representing various age groups including long-lived subjects up to the age of 104 years. Our eQTL-based approach revealed for the first time that human longevity is associated with a depletion of metabolic pathways in a genotype-dependent and independent manner. Further analyses indicated that 20% of the differentially expressed genes are influenced by genetic variants i

SUBMITTER: Hasler R 

PROVIDER: S-EPMC5506416 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature