Ontology highlight
ABSTRACT:
SUBMITTER: Yu DM
PROVIDER: S-EPMC5506423 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Aging cell 20170517 4
Paradoxical observations have been made regarding the role of caveolin-1 (Cav-1) during cellular senescence. For example, caveolin-1 deficiency prevents reactive oxygen species-induced cellular senescence despite mitochondrial dysfunction, which leads to senescence. To resolve this paradox, we re-addressed the role of caveolin-1 in cellular senescence in human diploid fibroblasts, A549, HCT116, and Cav-1<sup>-/-</sup> mouse embryonic fibroblasts. Cav-1 deficiency (knockout or knockdown) induced ...[more]