Identification of functional SNPs in the 5-prime flanking sequences of human genes.

ABSTRACT:

Background

Over 4 million single nucleotide polymorphisms (SNPs) are currently reported to exist within the human genome. Only a small fraction of these SNPs alter gene function or expression, and therefore might be associated with a cell phenotype. These functional SNPs are consequently important in understanding human health. Information related to functional SNPs in candidate disease genes is critical for cost effective genetic association studies, which attempt to understand the genetics of complex diseases like diabetes, Alzheimer's, etc. Robust methods for the identification of functional SNPs are therefore crucial. We report one such experimental approach.

Results

Sequence conserved between mouse and human genomes, within 5 kilobases of the 5-prime end of 176 GPCR gen

SUBMITTER: Mottagui-Tabar S 

PROVIDER: S-EPMC550646 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature