Protein sites with more coevolutionary connections tend to evolve slower, while more variable protein families acquire higher coevolutionary connections.

ABSTRACT: Background: Amino acid exchanges within proteins sometimes compensate for one another and could therefore be co-evolved. It is essential to investigate the intricate relationship between the extent of coevolution and the evolutionary variability exerted at individual protein sites, as well as the whole protein. Methods: In this study, we have used a reliable set of coevolutionary connections (sites within 10Å spatial distance) and investigated their correlation with the evolutionary diversity within the respective protein sites. Results: Based on our observations, we propose an interesting hypothesis that higher numbers of coevolutionary connections are associated with lesser evolutionary variable protein sites, while higher numbers of the coevolutionary connections ca

SUBMITTER: Mandloi S 

PROVIDER: S-EPMC5506539 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature