Investigation of poly(γ-glutamic acid) production via online determination of viscosity and oxygen transfer rate in shake flasks.

ABSTRACT:

Background

Poly(γ-glutamic acid) (γ-PGA) is a biopolymer with many useful properties making it applicable for instance in food and skin care industries, in wastewater treatment, in biodegradable plastics or in the pharmaceutical industry. γ-PGA is usually produced microbially by different Bacillus spp. The produced γ-PGA increases the viscosity of the fermentation broth. In case of shake flask fermentations, this results in an increase of the volumetric power input. The power input in shake flasks can be determined by measuring the torque of an orbitally rotating lab shaker. The online measurement of the volumetric power input enables to continuously monitor the formation or degradation of viscous products like γ-PGA. Combined with the online measurement of the oxygen transf

SUBMITTER: Regestein Nee Meissner L 

PROVIDER: S-EPMC5506581 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature