Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.

ABSTRACT:

Background

The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies. A new regimen to treat MDR-TB that includes pyrazinamide (PZA) is currently being evaluated and PZA resistance status will largely influence the success of current and future treatment strategies. PZA susceptibility testing was not routinely performed at the National Reference Laboratory (NRL) in Tbilisi between 2010 and September 2015. We here provide a first insight into the prevalence of PZA resistant TB in this region.

Methods

Phenotypic susceptibility to PZA was determined in a convenience collection of well-characterised TB patient isolates collected at the NRL in Tbilisi between 2012 and 2013. In addition, the pncA gene was

SUBMITTER: Sengstake S 

PROVIDER: S-EPMC5506614 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature