Hybrid polymeric matrices for oral modified release of Desvenlafaxine succinate tablets.

ABSTRACT: Purpose: Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which is rapidly absorbed after oral administration exaggerating its side effects. The current work aimed to prepare controllable release DSV matrix to reduce DSV side effects related to its initial burst. Methods: Fifteen DSV matrix formulations were prepared using different polymers, polymer/drug ratios and matrix excipients and characterized using Differential Scanning Calorimetry (DSC), infrared (IR) spectroscopy, water uptake and in vitro DSV release. The release kinetics were calculated to determine the drug release mechanism. Ex-vivo DSV absorption via rat intestinal mucosal cells and the calculation of the apparent permeability coefficient (P_app) were performed us

SUBMITTER: Samy W 

PROVIDER: S-EPMC5506642 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature