Epidemiology, Diagnosis, and Management of Neurogenic Orthostatic Hypotension.

ABSTRACT:

Background

Orthostatic hypotension (OH) is a sustained fall in blood pressure on standing which can cause symptoms of organ hypoperfusion. OH is associated with increased morbidity and mortality and leads to a significant number of hospital admissions particularly in the elderly (233 per 100,000 patients over 75 years of age in the US). OH can be due to volume depletion, blood loss, large varicose veins, medications, or due to defective activation of sympathetic nerves and reduced norepinephrine release upon standing (i.e., neurogenic OH).

Methods and findings

Literature review. Neurogenic OH is a frequent and disabling problem in patients with synucleinopathies such as Parkinson disease, multiple system atrophy, and pure autonomic failure, and is commonly associated with su

SUBMITTER: Palma JA 

PROVIDER: S-EPMC5506688 | biostudies-literature | 2017 May-Jun

REPOSITORIES: biostudies-literature