Altered emotional modulation of associative memory in first episode schizophrenia: An fMRI study.

ABSTRACT: Alterations of associative memory, resulting from perturbations within the medial temporal lobe, are well established in schizophrenia. So far, all the studies having examined associative memory in schizophrenia have limited ecological validity, as people experience various emotional stimuli in their life. As such, emotion must be taken into account in order to fully understand memory. Thus, we designed an fMRI study aimed at investigating neural correlates of the effects of emotions on associative memory in schizophrenia. Twenty-four first episode schizophrenia (FES) patients and 20 matched controls were instructed to memorize 90 pairs of standardized pictures during a scanned encoding phase. Each of the 90 pairs was composed of a scene and an unrelated object. Furthermore, trials were ei

SUBMITTER: Luck D 

PROVIDER: S-EPMC5506707 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature